Senior Machine Learning Scientist (US) — United States

What We Do

We build AI models to enable smaller, faster, and more successful clinical trials.

About 46F6c 2xu3

46F6c 2xu3 is a computational imaging company focused on improving how oncology trials measure treatment benefit. Our core technology is IPRO, an AI model that generates patient-level outcome predictions directly from routine medical imaging data. Our global biopharma customers use IPRO to predict efficacy, navigate billion-dollar development decisions with confidence, and move their most promising therapies through Phase I–III trials faster. IPRO is trained on the industry’s largest real-world imaging, clinical, and outcomes database, containing over 210 million longitudinal images and more than one million patient-years of linked outcomes.

Our multidisciplinary team of AI scientists, clinicians, and business operators is on a mission to get the most effective treatments to patients sooner. We collaborate closely with academic medical centers and co-publish our results at top-tier medical conferences.

fW75M is headquartered in Toronto, serves 6 of the top 20 global biopharmaceutical companies, and is backed by leading life sciences and technology investors.

What Makes This Role Compelling

• Unusually rich data: Access to large, diverse patient datasets with longitudinal outcomes across multiple cancer types

• Novel methodology: We're developing approaches that push beyond standard practices in medical imaging AI

• Multi-cancer generalization: Building methods that transfer across cancer types, not one-off solutions

Responsibilities & Expectations

• Design and implement deep learning architectures for 3D volumetric medical imaging (CT, PET, MRI)

• Develop survival models that handle censored outcomes, competing risks, and the statistical nuances of time-to-event prediction

• Optimize training pipelines to efficiently process large-scale imaging datasets on cloud GPU infrastructure

• Collaborate with our ML team to establish best practices and push the state of the art

• Contribute to research publications and present findings at conferences

Qualifications

• 7+ years of experience in machine learning, with substantial work in computer vision or medical imaging

• PhD in machine learning, computer vision, statistics, or a related field preferred; exceptional industry track record considered

• Deep expertise in 3D vision—experience with volumetric architectures (3D CNNs, Vision Transformers for 3D data, etc.)

• Strong foundation in survival analysis and time-to-event modeling (Cox models, deep survival models, competing risks)

• Proven ability to train large models efficiently at scale—you understand distributed training, memory optimization, and what it takes to iterate quickly on big data

• Proficiency with PyTorch and modern ML infrastructure

• Track record of impactful research (publications, deployed systems, or equivalent demonstrations of technical depth)

Nice To Have

• Experience with medical imaging foundation models or self-supervised learning on unlabeled imaging data

• Background in uncertainty quantification: calibrated predictions, conformal prediction, Bayesian deep learning

• MLOps experience: productionizing models, CI/CD for ML, model monitoring

• Familiarity with oncology, radiology, or regulated healthcare environments

Benefits

• Competitive pay and generous equity participation

• Coverage for medical, vision, and dental insurance

• 4 weeks of vacation per year

Compensation Range: $175K - $300K